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pgl-2 basic encoding a promoterless luciferase  (Promega)

 
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    Structured Review

    Promega pgl-2 basic encoding a promoterless luciferase
    Pgl 2 Basic Encoding A Promoterless Luciferase, supplied by Promega, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/pgl-2+basic/pgl2+based+ucp2+firefly+luciferase+constructs/pm32289262-310-4-12
    Average 90 stars, based on 1 article reviews
    pgl-2 basic encoding a promoterless luciferase - by Bioz Stars, 2026-09
    90/100 stars

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    Related Articles

    Amplification:

    Article Title: Effects of xenobiotics and peroxisome proliferator-activated receptor-alpha on the human UDPglucose dehydrogenase gene expression.
    Article Snippet: During drug metabolism, UDPglucuronate, a product of the reaction catalyzed by the enzyme UDPglucose dehydrogenase (UGDH), is conjugated with the metabolites to facilitate their elimination.. So far, it is not known whether xenobiotics can modulate the UGDH gene expression.. This question was tested by treating the human hepatoma cells HepG2 with several medicinal compounds and the UGDH gene expression analyzed by using real-time PCR.

    Article Title: Generation and characterization of tTS-H4: a novel transcriptional repressor that is compatible with the reverse tetracycline-controlled TET-ON system.
    Article Snippet: The resulting PCR fragment containing the murine HPRT promoter was 5′ inserted into the modified pIRESneo (Clontech) containing the destabilized d2EGFP coding region (from pd2EGFP-1, Clontech) followed by an intronic sequence, an intraribosomal entry site (IRES) and the firefly luciferase from pGL-2 basic (Promega).

    Article Title: Epidermal growth factor upregulates serotonin transporter in human intestinal epithelial cells via transcriptional mechanisms
    Article Snippet: The amplified 5′-flanking regions (hSERTp1 and hSERTp2) were then digested with Kpn I and Hin dIII enzymes and cloned into luciferase reporter gene vector pGL-2 basic (Promega, Madison, WI).

    Article Title: Regulation of connexin 43 by basic fibroblast growth factor in the bladder: transcriptional and behavioral implications.
    Article Snippet: Promoter-Reporter Assay We used the mouse pGL-2-Cx43 promoter-reporter pCx431686/ 165-Luc,23 and appropriate negative and control constructs, that is pGL-2 basic and pRL-TK, respectively (Promega, Madison, Wisconsin).

    Article Title: Mechanisms of transcriptional modulation of the human anion exchanger SLC26A3 gene expression by IFN-?
    Article Snippet: PCR products were then digested with Kpn I and Bgl II enzymes and cloned into luciferase reporter gene vector, pGL-2 basic (Promega).

    Article Title: ANGE gene in atopy
    Article Snippet: IgE Reporter Assays The human germline IgE promoter was cloned into the luciferase reporter vector pGL-2 Basic (Promega) in both forward and reverse orientations. pGL2 Control, in which the luciferase gene is under the control of the SV40 promoter (Promega), was used as a positive control for luciferase activity.

    Article Title: PKC-dependent stimulation of the human MCT1 promoter involves transcription factor AP2
    Article Snippet: PCR products were then digested with Xho1 and HindIII enzymes and subcloned into luciferase reporter gene vector, pGL-2 basic (Promega).

    Article Title: Characterization of the 5?-Flanking Region and Regulation of Expression of Human Anion Exchanger SLC26A6
    Article Snippet: The amplified 5′-flanking region was then digested with Kpn I and Sst I enzymes and cloned into luciferase reporter gene vector, pGL-2 basic (Promega).

    Clone Assay:

    Article Title: Effects of xenobiotics and peroxisome proliferator-activated receptor-alpha on the human UDPglucose dehydrogenase gene expression.
    Article Snippet: During drug metabolism, UDPglucuronate, a product of the reaction catalyzed by the enzyme UDPglucose dehydrogenase (UGDH), is conjugated with the metabolites to facilitate their elimination.. So far, it is not known whether xenobiotics can modulate the UGDH gene expression.. This question was tested by treating the human hepatoma cells HepG2 with several medicinal compounds and the UGDH gene expression analyzed by using real-time PCR.

    Article Title: Generation and characterization of tTS-H4: a novel transcriptional repressor that is compatible with the reverse tetracycline-controlled TET-ON system.
    Article Snippet: The resulting PCR fragment containing the murine HPRT promoter was 5′ inserted into the modified pIRESneo (Clontech) containing the destabilized d2EGFP coding region (from pd2EGFP-1, Clontech) followed by an intronic sequence, an intraribosomal entry site (IRES) and the firefly luciferase from pGL-2 basic (Promega).

    Article Title: Epidermal growth factor upregulates serotonin transporter in human intestinal epithelial cells via transcriptional mechanisms
    Article Snippet: The amplified 5′-flanking regions (hSERTp1 and hSERTp2) were then digested with Kpn I and Hin dIII enzymes and cloned into luciferase reporter gene vector pGL-2 basic (Promega, Madison, WI).

    Article Title: Regulation of connexin 43 by basic fibroblast growth factor in the bladder: transcriptional and behavioral implications.
    Article Snippet: Promoter-Reporter Assay We used the mouse pGL-2-Cx43 promoter-reporter pCx431686/ 165-Luc,23 and appropriate negative and control constructs, that is pGL-2 basic and pRL-TK, respectively (Promega, Madison, Wisconsin).

    Article Title: Mechanisms of transcriptional modulation of the human anion exchanger SLC26A3 gene expression by IFN-?
    Article Snippet: PCR products were then digested with Kpn I and Bgl II enzymes and cloned into luciferase reporter gene vector, pGL-2 basic (Promega).

    Article Title: ANGE gene in atopy
    Article Snippet: IgE Reporter Assays The human germline IgE promoter was cloned into the luciferase reporter vector pGL-2 Basic (Promega) in both forward and reverse orientations. pGL2 Control, in which the luciferase gene is under the control of the SV40 promoter (Promega), was used as a positive control for luciferase activity.

    Article Title: PKC-dependent stimulation of the human MCT1 promoter involves transcription factor AP2
    Article Snippet: PCR products were then digested with Xho1 and HindIII enzymes and subcloned into luciferase reporter gene vector, pGL-2 basic (Promega).

    Article Title: Characterization of the 5?-Flanking Region and Regulation of Expression of Human Anion Exchanger SLC26A6
    Article Snippet: The amplified 5′-flanking region was then digested with Kpn I and Sst I enzymes and cloned into luciferase reporter gene vector, pGL-2 basic (Promega).

    Luciferase:

    Article Title: Effects of xenobiotics and peroxisome proliferator-activated receptor-alpha on the human UDPglucose dehydrogenase gene expression.
    Article Snippet: During drug metabolism, UDPglucuronate, a product of the reaction catalyzed by the enzyme UDPglucose dehydrogenase (UGDH), is conjugated with the metabolites to facilitate their elimination.. So far, it is not known whether xenobiotics can modulate the UGDH gene expression.. This question was tested by treating the human hepatoma cells HepG2 with several medicinal compounds and the UGDH gene expression analyzed by using real-time PCR.

    Article Title: Generation and characterization of tTS-H4: a novel transcriptional repressor that is compatible with the reverse tetracycline-controlled TET-ON system.
    Article Snippet: The resulting PCR fragment containing the murine HPRT promoter was 5′ inserted into the modified pIRESneo (Clontech) containing the destabilized d2EGFP coding region (from pd2EGFP-1, Clontech) followed by an intronic sequence, an intraribosomal entry site (IRES) and the firefly luciferase from pGL-2 basic (Promega).

    Article Title: Epidermal growth factor upregulates serotonin transporter in human intestinal epithelial cells via transcriptional mechanisms
    Article Snippet: The amplified 5′-flanking regions (hSERTp1 and hSERTp2) were then digested with Kpn I and Hin dIII enzymes and cloned into luciferase reporter gene vector pGL-2 basic (Promega, Madison, WI).

    Article Title: Regulation of connexin 43 by basic fibroblast growth factor in the bladder: transcriptional and behavioral implications.
    Article Snippet: Promoter-Reporter Assay We used the mouse pGL-2-Cx43 promoter-reporter pCx431686/ 165-Luc,23 and appropriate negative and control constructs, that is pGL-2 basic and pRL-TK, respectively (Promega, Madison, Wisconsin).

    Article Title: Mechanisms of transcriptional modulation of the human anion exchanger SLC26A3 gene expression by IFN-?
    Article Snippet: PCR products were then digested with Kpn I and Bgl II enzymes and cloned into luciferase reporter gene vector, pGL-2 basic (Promega).

    Article Title: ANGE gene in atopy
    Article Snippet: IgE Reporter Assays The human germline IgE promoter was cloned into the luciferase reporter vector pGL-2 Basic (Promega) in both forward and reverse orientations. pGL2 Control, in which the luciferase gene is under the control of the SV40 promoter (Promega), was used as a positive control for luciferase activity.

    Article Title: PKC-dependent stimulation of the human MCT1 promoter involves transcription factor AP2
    Article Snippet: PCR products were then digested with Xho1 and HindIII enzymes and subcloned into luciferase reporter gene vector, pGL-2 basic (Promega).

    Article Title: Characterization of the 5?-Flanking Region and Regulation of Expression of Human Anion Exchanger SLC26A6
    Article Snippet: The amplified 5′-flanking region was then digested with Kpn I and Sst I enzymes and cloned into luciferase reporter gene vector, pGL-2 basic (Promega).

    Plasmid Preparation:

    Article Title: Effects of xenobiotics and peroxisome proliferator-activated receptor-alpha on the human UDPglucose dehydrogenase gene expression.
    Article Snippet: During drug metabolism, UDPglucuronate, a product of the reaction catalyzed by the enzyme UDPglucose dehydrogenase (UGDH), is conjugated with the metabolites to facilitate their elimination.. So far, it is not known whether xenobiotics can modulate the UGDH gene expression.. This question was tested by treating the human hepatoma cells HepG2 with several medicinal compounds and the UGDH gene expression analyzed by using real-time PCR.

    Article Title: Generation and characterization of tTS-H4: a novel transcriptional repressor that is compatible with the reverse tetracycline-controlled TET-ON system.
    Article Snippet: The resulting PCR fragment containing the murine HPRT promoter was 5′ inserted into the modified pIRESneo (Clontech) containing the destabilized d2EGFP coding region (from pd2EGFP-1, Clontech) followed by an intronic sequence, an intraribosomal entry site (IRES) and the firefly luciferase from pGL-2 basic (Promega).

    Article Title: Epidermal growth factor upregulates serotonin transporter in human intestinal epithelial cells via transcriptional mechanisms
    Article Snippet: The amplified 5′-flanking regions (hSERTp1 and hSERTp2) were then digested with Kpn I and Hin dIII enzymes and cloned into luciferase reporter gene vector pGL-2 basic (Promega, Madison, WI).

    Article Title: Regulation of connexin 43 by basic fibroblast growth factor in the bladder: transcriptional and behavioral implications.
    Article Snippet: Promoter-Reporter Assay We used the mouse pGL-2-Cx43 promoter-reporter pCx431686/ 165-Luc,23 and appropriate negative and control constructs, that is pGL-2 basic and pRL-TK, respectively (Promega, Madison, Wisconsin).

    Article Title: Mechanisms of transcriptional modulation of the human anion exchanger SLC26A3 gene expression by IFN-?
    Article Snippet: PCR products were then digested with Kpn I and Bgl II enzymes and cloned into luciferase reporter gene vector, pGL-2 basic (Promega).

    Article Title: ANGE gene in atopy
    Article Snippet: IgE Reporter Assays The human germline IgE promoter was cloned into the luciferase reporter vector pGL-2 Basic (Promega) in both forward and reverse orientations. pGL2 Control, in which the luciferase gene is under the control of the SV40 promoter (Promega), was used as a positive control for luciferase activity.

    Article Title: PKC-dependent stimulation of the human MCT1 promoter involves transcription factor AP2
    Article Snippet: PCR products were then digested with Xho1 and HindIII enzymes and subcloned into luciferase reporter gene vector, pGL-2 basic (Promega).

    Article Title: Characterization of the 5?-Flanking Region and Regulation of Expression of Human Anion Exchanger SLC26A6
    Article Snippet: The amplified 5′-flanking region was then digested with Kpn I and Sst I enzymes and cloned into luciferase reporter gene vector, pGL-2 basic (Promega).

    Control:

    Article Title: Effects of xenobiotics and peroxisome proliferator-activated receptor-alpha on the human UDPglucose dehydrogenase gene expression.
    Article Snippet: During drug metabolism, UDPglucuronate, a product of the reaction catalyzed by the enzyme UDPglucose dehydrogenase (UGDH), is conjugated with the metabolites to facilitate their elimination.. So far, it is not known whether xenobiotics can modulate the UGDH gene expression.. This question was tested by treating the human hepatoma cells HepG2 with several medicinal compounds and the UGDH gene expression analyzed by using real-time PCR.

    Article Title: Generation and characterization of tTS-H4: a novel transcriptional repressor that is compatible with the reverse tetracycline-controlled TET-ON system.
    Article Snippet: The resulting PCR fragment containing the murine HPRT promoter was 5′ inserted into the modified pIRESneo (Clontech) containing the destabilized d2EGFP coding region (from pd2EGFP-1, Clontech) followed by an intronic sequence, an intraribosomal entry site (IRES) and the firefly luciferase from pGL-2 basic (Promega).

    Article Title: Epidermal growth factor upregulates serotonin transporter in human intestinal epithelial cells via transcriptional mechanisms
    Article Snippet: The amplified 5′-flanking regions (hSERTp1 and hSERTp2) were then digested with Kpn I and Hin dIII enzymes and cloned into luciferase reporter gene vector pGL-2 basic (Promega, Madison, WI).

    Article Title: Regulation of connexin 43 by basic fibroblast growth factor in the bladder: transcriptional and behavioral implications.
    Article Snippet: Promoter-Reporter Assay We used the mouse pGL-2-Cx43 promoter-reporter pCx431686/ 165-Luc,23 and appropriate negative and control constructs, that is pGL-2 basic and pRL-TK, respectively (Promega, Madison, Wisconsin).

    Article Title: Mechanisms of transcriptional modulation of the human anion exchanger SLC26A3 gene expression by IFN-?
    Article Snippet: PCR products were then digested with Kpn I and Bgl II enzymes and cloned into luciferase reporter gene vector, pGL-2 basic (Promega).

    Article Title: ANGE gene in atopy
    Article Snippet: IgE Reporter Assays The human germline IgE promoter was cloned into the luciferase reporter vector pGL-2 Basic (Promega) in both forward and reverse orientations. pGL2 Control, in which the luciferase gene is under the control of the SV40 promoter (Promega), was used as a positive control for luciferase activity.

    Article Title: PKC-dependent stimulation of the human MCT1 promoter involves transcription factor AP2
    Article Snippet: PCR products were then digested with Xho1 and HindIII enzymes and subcloned into luciferase reporter gene vector, pGL-2 basic (Promega).

    Article Title: Characterization of the 5?-Flanking Region and Regulation of Expression of Human Anion Exchanger SLC26A6
    Article Snippet: The amplified 5′-flanking region was then digested with Kpn I and Sst I enzymes and cloned into luciferase reporter gene vector, pGL-2 basic (Promega).

    Construct:

    Article Title: Effects of xenobiotics and peroxisome proliferator-activated receptor-alpha on the human UDPglucose dehydrogenase gene expression.
    Article Snippet: During drug metabolism, UDPglucuronate, a product of the reaction catalyzed by the enzyme UDPglucose dehydrogenase (UGDH), is conjugated with the metabolites to facilitate their elimination.. So far, it is not known whether xenobiotics can modulate the UGDH gene expression.. This question was tested by treating the human hepatoma cells HepG2 with several medicinal compounds and the UGDH gene expression analyzed by using real-time PCR.

    Article Title: Generation and characterization of tTS-H4: a novel transcriptional repressor that is compatible with the reverse tetracycline-controlled TET-ON system.
    Article Snippet: The resulting PCR fragment containing the murine HPRT promoter was 5′ inserted into the modified pIRESneo (Clontech) containing the destabilized d2EGFP coding region (from pd2EGFP-1, Clontech) followed by an intronic sequence, an intraribosomal entry site (IRES) and the firefly luciferase from pGL-2 basic (Promega).

    Article Title: Epidermal growth factor upregulates serotonin transporter in human intestinal epithelial cells via transcriptional mechanisms
    Article Snippet: The amplified 5′-flanking regions (hSERTp1 and hSERTp2) were then digested with Kpn I and Hin dIII enzymes and cloned into luciferase reporter gene vector pGL-2 basic (Promega, Madison, WI).

    Article Title: Regulation of connexin 43 by basic fibroblast growth factor in the bladder: transcriptional and behavioral implications.
    Article Snippet: Promoter-Reporter Assay We used the mouse pGL-2-Cx43 promoter-reporter pCx431686/ 165-Luc,23 and appropriate negative and control constructs, that is pGL-2 basic and pRL-TK, respectively (Promega, Madison, Wisconsin).

    Article Title: Mechanisms of transcriptional modulation of the human anion exchanger SLC26A3 gene expression by IFN-?
    Article Snippet: PCR products were then digested with Kpn I and Bgl II enzymes and cloned into luciferase reporter gene vector, pGL-2 basic (Promega).

    Article Title: ANGE gene in atopy
    Article Snippet: IgE Reporter Assays The human germline IgE promoter was cloned into the luciferase reporter vector pGL-2 Basic (Promega) in both forward and reverse orientations. pGL2 Control, in which the luciferase gene is under the control of the SV40 promoter (Promega), was used as a positive control for luciferase activity.

    Article Title: PKC-dependent stimulation of the human MCT1 promoter involves transcription factor AP2
    Article Snippet: PCR products were then digested with Xho1 and HindIII enzymes and subcloned into luciferase reporter gene vector, pGL-2 basic (Promega).

    Article Title: Characterization of the 5?-Flanking Region and Regulation of Expression of Human Anion Exchanger SLC26A6
    Article Snippet: The amplified 5′-flanking region was then digested with Kpn I and Sst I enzymes and cloned into luciferase reporter gene vector, pGL-2 basic (Promega).

    Polymerase Chain Reaction:

    Article Title: Effects of xenobiotics and peroxisome proliferator-activated receptor-alpha on the human UDPglucose dehydrogenase gene expression.
    Article Snippet: During drug metabolism, UDPglucuronate, a product of the reaction catalyzed by the enzyme UDPglucose dehydrogenase (UGDH), is conjugated with the metabolites to facilitate their elimination.. So far, it is not known whether xenobiotics can modulate the UGDH gene expression.. This question was tested by treating the human hepatoma cells HepG2 with several medicinal compounds and the UGDH gene expression analyzed by using real-time PCR.

    Article Title: Generation and characterization of tTS-H4: a novel transcriptional repressor that is compatible with the reverse tetracycline-controlled TET-ON system.
    Article Snippet: The resulting PCR fragment containing the murine HPRT promoter was 5′ inserted into the modified pIRESneo (Clontech) containing the destabilized d2EGFP coding region (from pd2EGFP-1, Clontech) followed by an intronic sequence, an intraribosomal entry site (IRES) and the firefly luciferase from pGL-2 basic (Promega).

    Article Title: Epidermal growth factor upregulates serotonin transporter in human intestinal epithelial cells via transcriptional mechanisms
    Article Snippet: The amplified 5′-flanking regions (hSERTp1 and hSERTp2) were then digested with Kpn I and Hin dIII enzymes and cloned into luciferase reporter gene vector pGL-2 basic (Promega, Madison, WI).

    Article Title: Regulation of connexin 43 by basic fibroblast growth factor in the bladder: transcriptional and behavioral implications.
    Article Snippet: Promoter-Reporter Assay We used the mouse pGL-2-Cx43 promoter-reporter pCx431686/ 165-Luc,23 and appropriate negative and control constructs, that is pGL-2 basic and pRL-TK, respectively (Promega, Madison, Wisconsin).

    Article Title: Mechanisms of transcriptional modulation of the human anion exchanger SLC26A3 gene expression by IFN-?
    Article Snippet: PCR products were then digested with Kpn I and Bgl II enzymes and cloned into luciferase reporter gene vector, pGL-2 basic (Promega).

    Article Title: ANGE gene in atopy
    Article Snippet: IgE Reporter Assays The human germline IgE promoter was cloned into the luciferase reporter vector pGL-2 Basic (Promega) in both forward and reverse orientations. pGL2 Control, in which the luciferase gene is under the control of the SV40 promoter (Promega), was used as a positive control for luciferase activity.

    Article Title: PKC-dependent stimulation of the human MCT1 promoter involves transcription factor AP2
    Article Snippet: PCR products were then digested with Xho1 and HindIII enzymes and subcloned into luciferase reporter gene vector, pGL-2 basic (Promega).

    Article Title: Characterization of the 5?-Flanking Region and Regulation of Expression of Human Anion Exchanger SLC26A6
    Article Snippet: The amplified 5′-flanking region was then digested with Kpn I and Sst I enzymes and cloned into luciferase reporter gene vector, pGL-2 basic (Promega).

    Positive Control:

    Article Title: Effects of xenobiotics and peroxisome proliferator-activated receptor-alpha on the human UDPglucose dehydrogenase gene expression.
    Article Snippet: During drug metabolism, UDPglucuronate, a product of the reaction catalyzed by the enzyme UDPglucose dehydrogenase (UGDH), is conjugated with the metabolites to facilitate their elimination.. So far, it is not known whether xenobiotics can modulate the UGDH gene expression.. This question was tested by treating the human hepatoma cells HepG2 with several medicinal compounds and the UGDH gene expression analyzed by using real-time PCR.

    Article Title: Generation and characterization of tTS-H4: a novel transcriptional repressor that is compatible with the reverse tetracycline-controlled TET-ON system.
    Article Snippet: The resulting PCR fragment containing the murine HPRT promoter was 5′ inserted into the modified pIRESneo (Clontech) containing the destabilized d2EGFP coding region (from pd2EGFP-1, Clontech) followed by an intronic sequence, an intraribosomal entry site (IRES) and the firefly luciferase from pGL-2 basic (Promega).

    Article Title: Epidermal growth factor upregulates serotonin transporter in human intestinal epithelial cells via transcriptional mechanisms
    Article Snippet: The amplified 5′-flanking regions (hSERTp1 and hSERTp2) were then digested with Kpn I and Hin dIII enzymes and cloned into luciferase reporter gene vector pGL-2 basic (Promega, Madison, WI).

    Article Title: Regulation of connexin 43 by basic fibroblast growth factor in the bladder: transcriptional and behavioral implications.
    Article Snippet: Promoter-Reporter Assay We used the mouse pGL-2-Cx43 promoter-reporter pCx431686/ 165-Luc,23 and appropriate negative and control constructs, that is pGL-2 basic and pRL-TK, respectively (Promega, Madison, Wisconsin).

    Article Title: Mechanisms of transcriptional modulation of the human anion exchanger SLC26A3 gene expression by IFN-?
    Article Snippet: PCR products were then digested with Kpn I and Bgl II enzymes and cloned into luciferase reporter gene vector, pGL-2 basic (Promega).

    Article Title: ANGE gene in atopy
    Article Snippet: IgE Reporter Assays The human germline IgE promoter was cloned into the luciferase reporter vector pGL-2 Basic (Promega) in both forward and reverse orientations. pGL2 Control, in which the luciferase gene is under the control of the SV40 promoter (Promega), was used as a positive control for luciferase activity.

    Article Title: PKC-dependent stimulation of the human MCT1 promoter involves transcription factor AP2
    Article Snippet: PCR products were then digested with Xho1 and HindIII enzymes and subcloned into luciferase reporter gene vector, pGL-2 basic (Promega).

    Article Title: Characterization of the 5?-Flanking Region and Regulation of Expression of Human Anion Exchanger SLC26A6
    Article Snippet: The amplified 5′-flanking region was then digested with Kpn I and Sst I enzymes and cloned into luciferase reporter gene vector, pGL-2 basic (Promega).

    Activity Assay:

    Article Title: Effects of xenobiotics and peroxisome proliferator-activated receptor-alpha on the human UDPglucose dehydrogenase gene expression.
    Article Snippet: During drug metabolism, UDPglucuronate, a product of the reaction catalyzed by the enzyme UDPglucose dehydrogenase (UGDH), is conjugated with the metabolites to facilitate their elimination.. So far, it is not known whether xenobiotics can modulate the UGDH gene expression.. This question was tested by treating the human hepatoma cells HepG2 with several medicinal compounds and the UGDH gene expression analyzed by using real-time PCR.

    Article Title: Generation and characterization of tTS-H4: a novel transcriptional repressor that is compatible with the reverse tetracycline-controlled TET-ON system.
    Article Snippet: The resulting PCR fragment containing the murine HPRT promoter was 5′ inserted into the modified pIRESneo (Clontech) containing the destabilized d2EGFP coding region (from pd2EGFP-1, Clontech) followed by an intronic sequence, an intraribosomal entry site (IRES) and the firefly luciferase from pGL-2 basic (Promega).

    Article Title: Epidermal growth factor upregulates serotonin transporter in human intestinal epithelial cells via transcriptional mechanisms
    Article Snippet: The amplified 5′-flanking regions (hSERTp1 and hSERTp2) were then digested with Kpn I and Hin dIII enzymes and cloned into luciferase reporter gene vector pGL-2 basic (Promega, Madison, WI).

    Article Title: Regulation of connexin 43 by basic fibroblast growth factor in the bladder: transcriptional and behavioral implications.
    Article Snippet: Promoter-Reporter Assay We used the mouse pGL-2-Cx43 promoter-reporter pCx431686/ 165-Luc,23 and appropriate negative and control constructs, that is pGL-2 basic and pRL-TK, respectively (Promega, Madison, Wisconsin).

    Article Title: Mechanisms of transcriptional modulation of the human anion exchanger SLC26A3 gene expression by IFN-?
    Article Snippet: PCR products were then digested with Kpn I and Bgl II enzymes and cloned into luciferase reporter gene vector, pGL-2 basic (Promega).

    Article Title: ANGE gene in atopy
    Article Snippet: IgE Reporter Assays The human germline IgE promoter was cloned into the luciferase reporter vector pGL-2 Basic (Promega) in both forward and reverse orientations. pGL2 Control, in which the luciferase gene is under the control of the SV40 promoter (Promega), was used as a positive control for luciferase activity.

    Article Title: PKC-dependent stimulation of the human MCT1 promoter involves transcription factor AP2
    Article Snippet: PCR products were then digested with Xho1 and HindIII enzymes and subcloned into luciferase reporter gene vector, pGL-2 basic (Promega).

    Article Title: Characterization of the 5?-Flanking Region and Regulation of Expression of Human Anion Exchanger SLC26A6
    Article Snippet: The amplified 5′-flanking region was then digested with Kpn I and Sst I enzymes and cloned into luciferase reporter gene vector, pGL-2 basic (Promega).

    Modification:

    Article Title: Effects of xenobiotics and peroxisome proliferator-activated receptor-alpha on the human UDPglucose dehydrogenase gene expression.
    Article Snippet: During drug metabolism, UDPglucuronate, a product of the reaction catalyzed by the enzyme UDPglucose dehydrogenase (UGDH), is conjugated with the metabolites to facilitate their elimination.. So far, it is not known whether xenobiotics can modulate the UGDH gene expression.. This question was tested by treating the human hepatoma cells HepG2 with several medicinal compounds and the UGDH gene expression analyzed by using real-time PCR.

    Article Title: Generation and characterization of tTS-H4: a novel transcriptional repressor that is compatible with the reverse tetracycline-controlled TET-ON system.
    Article Snippet: The resulting PCR fragment containing the murine HPRT promoter was 5′ inserted into the modified pIRESneo (Clontech) containing the destabilized d2EGFP coding region (from pd2EGFP-1, Clontech) followed by an intronic sequence, an intraribosomal entry site (IRES) and the firefly luciferase from pGL-2 basic (Promega).

    Article Title: Epidermal growth factor upregulates serotonin transporter in human intestinal epithelial cells via transcriptional mechanisms
    Article Snippet: The amplified 5′-flanking regions (hSERTp1 and hSERTp2) were then digested with Kpn I and Hin dIII enzymes and cloned into luciferase reporter gene vector pGL-2 basic (Promega, Madison, WI).

    Article Title: Regulation of connexin 43 by basic fibroblast growth factor in the bladder: transcriptional and behavioral implications.
    Article Snippet: Promoter-Reporter Assay We used the mouse pGL-2-Cx43 promoter-reporter pCx431686/ 165-Luc,23 and appropriate negative and control constructs, that is pGL-2 basic and pRL-TK, respectively (Promega, Madison, Wisconsin).

    Article Title: Mechanisms of transcriptional modulation of the human anion exchanger SLC26A3 gene expression by IFN-?
    Article Snippet: PCR products were then digested with Kpn I and Bgl II enzymes and cloned into luciferase reporter gene vector, pGL-2 basic (Promega).

    Article Title: ANGE gene in atopy
    Article Snippet: IgE Reporter Assays The human germline IgE promoter was cloned into the luciferase reporter vector pGL-2 Basic (Promega) in both forward and reverse orientations. pGL2 Control, in which the luciferase gene is under the control of the SV40 promoter (Promega), was used as a positive control for luciferase activity.

    Article Title: PKC-dependent stimulation of the human MCT1 promoter involves transcription factor AP2
    Article Snippet: PCR products were then digested with Xho1 and HindIII enzymes and subcloned into luciferase reporter gene vector, pGL-2 basic (Promega).

    Article Title: Characterization of the 5?-Flanking Region and Regulation of Expression of Human Anion Exchanger SLC26A6
    Article Snippet: The amplified 5′-flanking region was then digested with Kpn I and Sst I enzymes and cloned into luciferase reporter gene vector, pGL-2 basic (Promega).

    Sequencing:

    Article Title: Effects of xenobiotics and peroxisome proliferator-activated receptor-alpha on the human UDPglucose dehydrogenase gene expression.
    Article Snippet: During drug metabolism, UDPglucuronate, a product of the reaction catalyzed by the enzyme UDPglucose dehydrogenase (UGDH), is conjugated with the metabolites to facilitate their elimination.. So far, it is not known whether xenobiotics can modulate the UGDH gene expression.. This question was tested by treating the human hepatoma cells HepG2 with several medicinal compounds and the UGDH gene expression analyzed by using real-time PCR.

    Article Title: Generation and characterization of tTS-H4: a novel transcriptional repressor that is compatible with the reverse tetracycline-controlled TET-ON system.
    Article Snippet: The resulting PCR fragment containing the murine HPRT promoter was 5′ inserted into the modified pIRESneo (Clontech) containing the destabilized d2EGFP coding region (from pd2EGFP-1, Clontech) followed by an intronic sequence, an intraribosomal entry site (IRES) and the firefly luciferase from pGL-2 basic (Promega).

    Article Title: Epidermal growth factor upregulates serotonin transporter in human intestinal epithelial cells via transcriptional mechanisms
    Article Snippet: The amplified 5′-flanking regions (hSERTp1 and hSERTp2) were then digested with Kpn I and Hin dIII enzymes and cloned into luciferase reporter gene vector pGL-2 basic (Promega, Madison, WI).

    Article Title: Regulation of connexin 43 by basic fibroblast growth factor in the bladder: transcriptional and behavioral implications.
    Article Snippet: Promoter-Reporter Assay We used the mouse pGL-2-Cx43 promoter-reporter pCx431686/ 165-Luc,23 and appropriate negative and control constructs, that is pGL-2 basic and pRL-TK, respectively (Promega, Madison, Wisconsin).

    Article Title: Mechanisms of transcriptional modulation of the human anion exchanger SLC26A3 gene expression by IFN-?
    Article Snippet: PCR products were then digested with Kpn I and Bgl II enzymes and cloned into luciferase reporter gene vector, pGL-2 basic (Promega).

    Article Title: ANGE gene in atopy
    Article Snippet: IgE Reporter Assays The human germline IgE promoter was cloned into the luciferase reporter vector pGL-2 Basic (Promega) in both forward and reverse orientations. pGL2 Control, in which the luciferase gene is under the control of the SV40 promoter (Promega), was used as a positive control for luciferase activity.

    Article Title: PKC-dependent stimulation of the human MCT1 promoter involves transcription factor AP2
    Article Snippet: PCR products were then digested with Xho1 and HindIII enzymes and subcloned into luciferase reporter gene vector, pGL-2 basic (Promega).

    Article Title: Characterization of the 5?-Flanking Region and Regulation of Expression of Human Anion Exchanger SLC26A6
    Article Snippet: The amplified 5′-flanking region was then digested with Kpn I and Sst I enzymes and cloned into luciferase reporter gene vector, pGL-2 basic (Promega).



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